The Role of Peripheral Inflammation on Brain Damage
Traumatic Brain Injury (TBI) and cerebral ischemia trigger a loss of brain tissue and, subsequently, a strong inflammatory response in the brain. In addition, brain damage can alter the function of peripheral regions and other organs, eliciting systemic responses, and global consequences. A focal injury to the brain elicits a rapid hepatic response; the production of chemokines by the liver acts as an amplifier of the focal injury response providing a route of CNS-liver communication. However, little is currently known regarding the inflammatory mediators and acute-phase proteins involved in the peripheral regions after brain injury, such as the liver. Furthermore, the extent of damage TBI inflicts on the peripheral organs remains largely unexplored.
Can a concussion change your gut microbiota?
Athletes who participate in contact sports are at risk of suffering from concussions, which can result in chronic headaches, nausea, anxiety and depression. Head injury also induces intestinal changes, including to microbes found in the gut; and the brain, in turn, can react to signals from the intestinal microbiome. This interaction is called the “brain-gut” axis. The results from this study will help us to identify temporal sequelae and biomarkers of head injury and will lead us to new treatments to prevent the consequences of concussions.