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Peer-Reviewed Research Articles and reviews

  1. Molino S, Pisarevsky A, Mingorance FL, Vega P, Stefanolo JP, Repetti J, Ludueña G, Pepa P, Olmos JI, Fermepin MR, Uehara T, Villapol S, Savidge T, Treangen T, Viciani E, Castagnetti A, Piskorz MM. Natural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trial. 2021 Apr 28;22(1):310. doi: 10.1186/s13063-021-05281-x.PMID: 33910614.
  1. Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury

    Zinger, A., Soriano, S., Baudo, G., De Rosa, E.Taraballi, F. & Villapol, S.2021, (Accepted/In press) In: Advanced Functional Materials. Research outputContribution to journal › Article › peer-review

  2. White TM, Cash-Gibson L, Martin-Moreno JM, Matesanz R, Crespo J, Alfonso-Sanchez JL, Villapol S, El-Mohandes A, Lazarus JV. COVID-SCORE Spain: Public perceptions of key government COVID-19 control measures. Eur J Public Health. 2021 Apr 19:ckab066. doi: 10.1093/eurpub/ckab066. Online ahead of print.PMID: 33872348
  1. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo P, Cuapio A, Villapol S. More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis. Res Sq. 2021 Mar doi: 10.21203/ Preprint.PMID: 33688642.
  1. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S. More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis. 2021 Jan 30:2021.01.27.21250617. doi: 10.1101/2021.01.27.21250617. Preprint.PMID: 33532785
  1. Sapoval N, Mahmoud M, Jochum MD, Liu Y, Elworth RAL, Wang Q, Albin D, Ogilvie HA, Lee MD, Villapol S, Hernandez KM, Maljkovic Berry I, Foox J, Beheshti A, Ternus K, Aagaard KM, Posada D, Mason CE, Sedlazeck FJ, Treangen TJ. SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission. Genome Res. 2021 Apr;31(4):635-644. doi: 10.1101/gr.268961.120. Epub 2021 Feb 18.PMID: 33602693Free PMC article.
  1. Villapol S. Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome. Transl Res. 2020 Aug 20:S1931-5244(20)30199-7.
  1. Sapoval N, Mahmoud M, Jochum MD, Liu Y, Leo Elworth RA, Wang Q, Albin D, Ogilvie H, Lee MD,Villapol S, Hernandez KM, Berry IM, Foox J, Beheshti A, Ternus K, Aagaard KM, Posada D, Mason CE, Sedlazeck F, Treangen TJ. Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. 2020 Jul 2:2020.07.02.184481. doi: 10.1101/2020.07.02.184481. Preprint.PMID: 32637955
  1. Soriano S, Moffet B., Wicker E. Villapol, S. Serum Amyloid A is expressed in the brain after traumatic brain injury in a sex-dependent manner. Cell Mol Neurobiol. 2020 Feb 14. doi: 10.1007/s10571-020-00808-3. PMID:
  1. Villapol, S., Faivre, V., Joshi, P.; Moretti, R.; Besson, V.C.; Charriaut-Marlangue, C. Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke.  J. Mol. Sci.201920, 3809. PMID:31382688.
  1. Wicker E., Benton L., George K., Furlow W., Villapol S. Serum Amyloid A protein as a potential biomarker for severity and acute outcome in traumatic brain injury. Biomed Res Int. 2019 Apr 16;2019:5967816. PMID: 31119176.
  1. Treangen TJ., Wagner J, Burns MP., Villapol S. Traumatic brain injury in mice induces acute bacterial dysbiosis within the fecal microbiome. Front Immunol. 2018 Nov 27;9:2757. PMID:30546361.
  1. Main B., Villapol S., Sloley S., Barton D., Parsadanian M., Agbaegbu C, Stefos K., McCann M., Washington P, Rodriguez O., Burns MP. Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury. Mol Neurodegener. 2018 Apr 4;13(1):17. PMID: 29618365.
  1. Bozzelli, L., Alaiyed S., Kim E., Villapol S., Conant K. Proteolytic remodeling of perineuronal nets: effects on synaptic plasticity and neuronal population dynamics. Neural Plast. 2018 Feb 4;2018:5735789. PMID: 29531525.
  1. Lanfranco M.F., Burns M.P., Mocchetti I., Villapol S. Glial- and Neuronal-specific expression of CCL5 mRNA in the rat brain. Frontiers in Neuroanatomy, Neuroanat. 11:137. doi: 10.3389/fnana.2017.00137, 2018. PMID:29375328
  2. Lanfranco, M., Loane, D. J., Mocchetti, I., Burns, M. P. and Villapol, S*. Combination of Fluorescent in situHybridization (FISH) and Immunofluorescence Imaging for Detection of Cytokine Expression in Microglia/Macrophage Cells.  Bio Protoc. 2017 Nov 20;7(22). pii: e2608. doi: 10.21769/BioProtoc.2608. PMID:29238736
  1. Villapol S. Roles of Peroxisome Proliferator-Activated Receptor-gamma on brain and peripheral inflammation. Cell Mol Neurobiol. Cell Mol Neurobiol. 2018 Jan;38(1):121-132. doi: 10.1007/s10571-017-0554-5. Epub 2017 Oct 3. Review. PMID: 28975471
  1. Villapol S, Loane DJ, Burns MP. Sexual dimorphism in the inflammatory response to traumatic brain injury. 2017 Sep;65(9):1423-1438. doi: 10.1002/glia.23171. Epub 2017 Jun 13. PMID:28608978. Featured in News.
  1. Zhou, J, Burns, MP, Villapol S, Amdur R, Saavedra JM, Taub D, Blackman MR. Temporal changes in gene expression associated with glucose metabolism in cortex and hippocampus of mice after Controlled Cortical Impact Injury, Front Endocrinol (Lausanne). 2017 Sep 11;8:231. doi: 10.3389/fendo.2017.00231. eCollection 2017. PMID:28955302
  1. Main BS, Sloley S, Villapol S, Zapple DN, Burns MP. A mouse model of single and repetitive Mild Traumatic Brain Injury. J Vis Exp. 2017 Jun 20;(124). doi: 10.3791/55713. PMID:28654066
  1. Neustadtl A, Winston CN, Parsadanian P,Main BS, Villapol S and Burns MP. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. 2017 Jul 5;28(10):618-624. doi: 10.1097/WNR.0000000000000811. PMID:28542068
  1. Barrett J, Henry RJ, Villapol S, Stoica BA, Faden AI, Burns MP, Loane DJ. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for acute brain injury. J Neuroinflammation. 2017 Mar 24;14(1):65. doi: 10.1186/s12974-017-0843-4.PMID:28340575
  1. De Magalhaes Filho, C, Kappeler, L, Dupont, J, Solinc, J, Villapol S, Denis, C, Nosten-Bertrand, M, Billard, JM, Blaise, A, Tronche, F, Giros, B, Charriaut-Marlangue, C, Aïd, S, Le Bouc, Y, Holzenberger, M. Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin. J Cereb Blood Flow Metab. 2017 Feb;37(2):396-412. doi: 10.1177/0271678X15626718. PMID:26762506
  1. Allen M, Ghosh S, Ahern GP, Villapol S, Maguire-Zeiss KA, Conant K. Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1. Sci Rep. 2016 Oct 20;6:35497. doi: 10.1038/srep35497. PMID:27762280
  1. Villapol S. Consequences of hepatic damage after traumatic brain injury: current outlook and potential therapeutic targets. Neural Regen Res. 2016 Feb;11(2):226-7. doi: 10.4103/1673-5374.177720. PMID:27073366
  1. Winston CN, Noel A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E and Burns MP. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016 Mar;186(3):552-67. doi: 10.1016/j.ajpath.2015.11.006. PMID:26857506.
  1. Washington PM, Villapol S, Burns MP. Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should it be classified together as traumatic encephalopathy? Exp Neurol. 2016 Jan;275 Pt 3:381-388. doi: 10.1016/j.expneurol.2015.06.015. Review. PMID:26091850. Cover article.
  1. Villapol S, Kryndushkin D, Balarezo M, Campbell A, Saavedra JM, Shewmaker FP, Symes AJ. Hepatic expression of Serum Amyloid A1 is induced by traumatic brain injury and modulated by telmisartan. Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016. PMID:26435412. Featured in News.
  1. Villapol S, Balarezo M, Affram K, Saavedra JM, Symes AJ. Neurorestoration after traumatic brain injury through Angiotensin II receptor blockage. 2015 Nov;138(Pt 11):3299-315. doi: 10.1093/brain/awv172. PMID:26115674.Featured in News.
  1. Villapol S, and Saavedra JM. Neuroprotective effects of angiotensin receptor blockers. Review. Am J Hypertens. 2015 Mar;28(3):289-99. doi: 10.1093/ajh/hpu197. Epub 2014 Oct 31. Review. PMID: 25362113.
  1. Villapol S, Byrnes K, Symes AJ. Temporal dynamics of astrocytes-vasculature interaction, astrogliosis and apoptosis that occurs in the pericontusional cortical brain after traumatic brain injury. Front Neurol. 2014 Jun 4;5:82. doi: 10.3389/fneur.2014.00082. PMID:24926283
  1. Susarla B, Villapol S, Yi JH, Geller HM, Symes AJ. Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice. ASN Neuro. 2014 May 8;6(3):159-70. doi: 10.1042/AN20130034. PMID:24670035
  1. Villapol S, Wang Y, Adams M, Symes AJ. Smad3 deficiency increases cortical and hippocampal neuronal loss following traumatic brain injury. Exp Neurol. 2013 Dec;250:353-65. doi: 10.1016/j.expneurol.2013.10.008. Epub 2013 Oct 9. PMID:24120438
  1. Hafko R, Villapol S, Nostramo R, Symes AJ, Sabban EL, Inagami T,Saavedra JM. Commercially available Angiotensin II AT2 receptor antibodies are nonspecific. PLoS One. 2013 Jul 1;8(7):e69234. doi: 10.1371/journal.pone.0069234. PMID:23840911
  1. Logan TT, Villapol S, Symes AJ. TGF-β superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury. PLoS One. 2013;8(3):e59250. doi: 10.1371/journal.pone.0059250. PMID: 23555640
  1. Villapol S, Yaszemski AK, Logan TT, Sánchez-Lemus E, Saavedra JM, Symes AJ.  Candesartan, an Angiotensin II AT(1)-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice. 2012 Dec;37(13):2817-29. doi: 10.1038/npp.2012.152. PMID:22892395. Featured in News.
  1. Charriaut-Marlangue C, Bonnin P, Gharib A, Leger PL, Villapol S, Pocard M, Gressens P, Renolleau S, Baud O. Inhaled Nitric Oxide Reduces Brain Damage by Collateral Recruitment in a Neonatal Stroke Model. 2012 Nov;43(11):3078-84. doi: 10.1161/STROKEAHA.112.664243. PMID:22949477
  1. Bonnin P, Leger PL,Villapol S, Deroide N, Gressens P, Pocard M, Renolleau S, Baud O, Charriaut-Marlangue C. Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia. Exp Neurol. 2012 Jul;236(1):50-7. doi: 10.1016/j.expneurol.2012.04.001. PMID:22531298
  1. Villapol S, Fau S, Renolleau S, Biran V, Charriaut-Marlangue C, Baud O. Metatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. Pediatr Res. 2011 Jan;69(1):51-5. doi: 10.1203/PDR.0b013e3181fcb40b. PMID:20856166. Cover article.
  1. Villapol S, Bonnin P, Fau S, Baud O, Renolleau S, and Charriaut-Marlangue, C. Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain. Am J Pathol. 2009 Nov;175(5):2111-20. doi: 10.2353/ajpath.2009.090257. Epub 2009 Oct 8. PMID:19815715
  1. Gelot A, Villapol S, Renolleau S., and Charriaut-Marlangue, C., Astrocytic demise in the developing rat and human brain after hypoxic-ischemic damage, Dev Neurosci. 2009;31(5):459-70. doi: 10.1159/000232564. Epub 2009 Aug 11. PMID:19672074
  1. Villapol S, Gelot A, Renolleau S, and Charriaut-Marlangue C. Astrocyte responses after neonatal ischemia: the yin and the yang. 2008 Aug;14(4):339-44. doi: 10.1177/1073858408316003. Epub 2008 Jul 8. Review. PMID:18612085
  1. Faiz M, Acarin L, Villapol S, Castellano B, Gonzalez B. Substantial migration of SVZ cells to the cortex results in the generation of new neurons in the excitotoxically damaged immature rat brain. Mol Cell Neurosci. 2008 Jun;38(2):170-82. doi: 10.1016/j.mcn.2008.02.002. Epub 2008 Mar 4. PMID:18434192
  1. Villapol S, Acarin L, Faiz M, Castellano B, González B. Survivin and Heat Shock Protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain. 2008 Apr 22;153(1):108-19. doi: 10.1016/j.neuroscience. 2008.01.054. Epub 2008 Feb 14. PMID:18358624
  1. Villapol S, Acarin L, Faiz M, Castellano B, González B. Distintic spatial and temporal activation profile of apoptotic pathways in neurons and glial cells after excitotoxic damage in the neonatal rat brain. J Neurosci Res. 2007 Dec;85(16):3545-56. PMID:17668855
  1. Acarin L, Villapol S, Faiz M, Rohn TT, Castellano B, González B. Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation. 2007 Jul;55(9):954-65. PMID:17487878
  1. Spiegler M, Villapol S, Biran V, Goyenvalle C, Mariani J, Renolleau S, Charriaut-Marlangue C. Bilateral Changes after neonatal ischemia in the P7 rat brain. J Neuropathol Exp Neurol. 2007 Jun;66(6):481-90. PMID:17549008
  1. Faiz M, Acarin L, Peluffo H, Villapol S, Castellano B, Gonzalez B. Cu/Zn superoxide dismutase expression in progenitor and stem cells of the postnatal subventricular zone. Neurosci Lett. 2006 Jun 19;401(1-2):71-6. Epub 2006 Mar 29. PMID:16567040.

Book Chapters

Role of TGF-β Signaling in Neurogenic Regions After Brain Injury

Sonia Villapol, Trevor T. Logan, Aviva J. Symes. Book: Trends in Cell Signaling Pathways in Neuronal fateDecision. ISBN 978-953-51-1059-0, Hard cover, 358 pages, Publisher: InTech, Published: March 27, 2013

Neuropathology of traumatic brain injury and its role in the development of Alzheimer’s Disease

Sonia Villapol. Amyloidosis, IntechOpen,  2018. DOI: 10.5772/intechopen.81945.

Polypathology and Dementia After Brain Trauma: Does Brain Injury Trigger Distinct Neurodegenerative Diseases, or Should They be Classified Together as Traumatic Encephalopathy

Washington PM, Villapol S, Burns MP. Concussion and Traumatic Encephalopathy. Edited by Dr. Jeff Victoroff and Dr. Erin D. Bigler. Chapter 13, Pages 573-582, 2018. Cambridge University Press. ISBN: 9781139696432.