2025
70. Vonder HC, Celorrio M, Martens KM, Friess SH, Villapol S, Urban R, Pyles R, Mychasiuk R, Simon D, Dave A. The gut microbiome as a modulator of traumatic brain injury pathology and symptoms. J Neurosci. 12 November 2025, 45 (46) e1337252025; https://doi.org/10.1523/JNEUROSCI.1337-25.2025
69. Soriano S, Marshall A, Holcomb M, Flinn H, Burke M, Kara G, Scalzo P, Villapol S. Sex-specific effects of fecal microbiota transplantation on TBI-exacerbated Alzheimer’s pathology in mice. bioRxiv [Preprint]. 2025 Sep 17:2025.09.11.675717. doi: 10.1101/2025.09.11.675717. PMID: 41000801; PMCID: PMC12458186.
68. Flinn H, Marshall A, Holcomb M, Burke M, Cruz-Pineda L, Soriano S, Treangen TJ, Villapol S. Gut microbiome remodeling by antibiotics reduces neuroinflammation in traumatic brain injury. Res Sq [Preprint]. 2025 Sep 18:rs.3.rs-7411086. doi: 10.21203/rs.3.rs-7411086/v1. PMID: 41001537; PMCID: PMC12458575.
67. Holcomb M, Marshall A, Flinn H, Lozano M, Soriano S, Gomez-Pinilla F, Villapol S. Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice. J Neuroinflammation. 2025;22(1):114.
66. Scalzo PL, Marshall A, Soriano S, Curry K, Dulay M, Hodics T, Quingly EMM, Treangen TJ, Villapol S. Gut microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients. J Transl Med. 2025;23(1):327.
2024
65. Affram, K. O., Janatpour, Z. C., Shanbhag, N., Villapol, S., & Symes, A. J. Telmisartan Reduces LPS-Mediated Inflammation and Induces Autophagy of Microglia. (2024). Telmisartan Neuroglia, 5(2), 182-201. https://doi.org/10.3390/neuroglia5020014
64. Lopez-Espinosa J, Park P, Holcomb M, Godin B, Villapol S. Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review. Ther Deliv. 2024;15(12):997-1024.
63. Amaral WZ, Kokroko N, Treangen TJ, Villapol S, Gomez-Pinilla F. Probiotic therapy modulates the brain-gut-liver microbiota axis in a mouse model of traumatic brain injury. Biochim Biophys Acta Mol Basis Dis. 2024;1870(8):167483.
62. Holcomb M, Marshall A, Flinn H, Lozano M, Soriano S, Gomez-Pinilla F, Villapol S. Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice. Res Sq. 2024.
61. Flinn H, Marshall A, Holcomb M, Cruz L, Soriano S, Treangen TJ, Villapol S. Antibiotic treatment induces microbiome dysbiosis and reduction of neuroinflammation following traumatic brain injury in mice. Res Sq. 2024.
60. Flinn H, Cruz-Pineda L, Montier L, Horner PJ, Villapol S. iDISCO Tissue Clearing Whole-Brain and Light Sheet Microscopy for High-Throughput Imaging in a Mouse Model of Traumatic Brain Injury. Methods Mol Biol. 2024;2761:589-97.
59. Curry KD, Soriano S, Nute MG, Villapol S, Dilthey A, Treangen TJ. Microbial Community Profiling Protocol with Full-length 16S rRNA Sequences and Emu. Curr Protoc. 2024;4(3):e978.
58. Baudo G, Flinn H, Holcomb M, Tiwari A, Soriano S, Taraballi F, Villapol S. Sex-dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice. Bioeng Transl Med. 2024;9(4):e10647.
2023
57. Villapol S, Janatpour ZC, Affram KO, Symes AJ. The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury. Neurotherapeutics. 2023;20(6):1565-91.
56. Baudo G, Flinn H, Holcomb M, Tiwari A, Soriano S, Taraballi F, Villapol S. Sex-dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice. bioRxiv. 2023.
2022
55. Soriano S, Curry K, Wang Q, Chow E, Treangen TJ, Villapol S. Fecal Microbiota Transplantation Derived from Alzheimer’s Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls. Int J Mol Sci. 2022;23(9).
54. Soriano S, Curry K, Sadrameli SS, Wang Q, Nute M, Reeves E, Villapol S, et al. Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study. Brain Behav Immun Health. 2022;21:100438.
53. Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, Perelman C, Sepulveda R, Rebolledo PA, Villapol S. Long-COVID in children and adolescents: a systematic review and meta-analyses. Sci Rep. 2022;12(1):9950.
52. Lazarus JV, Romero D, Kopka CJ, Karim SA, Abu-Raddad LJ, Almeida G, et al. A multinational Delphi consensus to end the COVID-19 public health threat. Nature. 2022;611(7935):332-45.
51. Curry KD, Wang Q, Nute MG, Tyshaieva A, Reeves E, Soriano S, Villapol S, et al. Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data. Nat Methods. 2022;19(7):845-53.
2021
50. Zinger A, Soriano S, Baudo G, De Rosa E, Taraballi F, Villapol S. Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury. Adv Funct Mater. 2021;31(30):2100722.
49. White TM, Cash-Gibson L, Martin-Moreno JM, Matesanz R, Crespo J, Alfonso-Sanchez JL, et al. COVID-SCORE Spain: public perceptions of key government COVID-19 control measures. Eur J Public Health. 2021;31(5):1095-102.
48. Sapoval N, Mahmoud M, Jochum MD, Liu Y, Elworth RAL, Wang Q, Villapol S, et al. SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission. Genome Res. 2021;31(4):635-44.
47. Sadaf H, Desai VR, Misra V, Golanov E, Hegde ML, Villapol S, et al. A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage. Ann Clin Transl Neurol. 2021;8(11):2211-21.
46. Molino S, Pisarevsky A, Mingorance FL, Vega P, Stefanolo JP, Repetti J, et al. Natural tannin extracts supplementation for COVID-19 patients (TanCOVID). Trials. 2021;22(1):310.
45. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep. 2021;11(1):16144.
44. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo P, Cuapio A, Villapol S. More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis. Res Sq. 2021.
43. Lazarus JV, Bassat Q, Crespo J, Fanjul G, Garcia-Basteiro AL, Hoyos ML, Villapol S, et al. Vaccinate fast but leave no one behind: a call to action for COVID-19 vaccination in Spain. Commun Med (Lond). 2021;1:12.
2020
42. Villapol S. Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome. Transl Res. 2020;226:57-69.
41. Soriano S, Moffet B, Wicker E, Villapol S. Serum Amyloid A is Expressed in the Brain After Traumatic Brain Injury in a Sex-Dependent Manner. Cell Mol Neurobiol. 2020;40(7):1199-211.
40. Sapoval N, Mahmoud M, Jochum MD, Liu Y, Elworth RAL, Wang Q, Villapol S, et al. Hidden genomic diversity of SARS-CoV-2. bioRxiv. 2020.
2019
39. Wicker E, Benton L, George K, Furlow W, Villapol S. Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury. Biomed Res Int. 2019;2019:5967816.
38. Villapol S, Faivre V, Joshi P, Moretti R, Besson VC, Charriaut-Marlangue C. Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke. Int J Mol Sci. 2019;20(15).
2018
37. Villapol S. Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation. Cell Mol Neurobiol. 2018;38(1):121-32.
36. Treangen TJ, Wagner J, Burns MP, Villapol S. Traumatic Brain Injury in Mice Induces Acute Bacterial Dysbiosis Within the Fecal Microbiome. Front Immunol. 2018;9:2757.
35. Main BS, Villapol S, Sloley SS, Barton DJ, Parsadanian M, Agbaegbu C, et al. Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury. Mol Neurodegener. 2018;13(1):17.
34. Bozzelli PL, Alaiyed S, Kim E, Villapol S, Conant K. Proteolytic Remodeling of Perineuronal Nets. Neural Plast. 2018;2018:5735789.
2017
33. Zhou J, Burns MP, Huynh L, Villapol S, Taub DD, Saavedra JM, et al. Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice. Front Endocrinol (Lausanne). 2017;8:231.
32. Villapol S, Loane DJ, Burns MP. Sexual dimorphism in the inflammatory response to traumatic brain injury. Glia. 2017;65(9):1423-38.
31. Neustadtl AL, Winston CN, Parsadanian M, Main BS, Villapol S, Burns MP. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. Neuroreport. 2017;28(10):618-24.
30. Main BS, Sloley SS, Villapol S, Zapple DN, Burns MP. A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury. J Vis Exp. 2017(124).
29. Lanfranco MF, Mocchetti I, Burns MP, Villapol S. Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain. Front Neuroanat. 2017;11:137.
28. Fe Lanfranco M, Loane DJ, Mocchetti I, Burns MP, Villapol S. Combination of Fluorescent in situ Hybridization (FISH) and Immunofluorescence Imaging for Detection of Cytokine Expression in Microglia/Macrophage Cells. Bio Protoc. 2017;7(22).
27. De Magalhaes Filho CD, Kappeler L, Dupont J, Solinc J, Villapol S, Denis C, et al. Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin. J Cereb Blood Flow Metab. 2017;37(2):396-412.
26. Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, et al. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury. J Neuroinflammation. 2017;14(1):65.
2016
25. Winston CN, Noel A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Villapol S, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186(3):552-67.
24. Washington PM, Villapol S, Burns MP. Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy? Exp Neurol. 2016;275 Pt 3:381-8.
23. Villapol S. Consequences of hepatic damage after traumatic brain injury: current outlook and potential therapeutic targets. Neural Regen Res. 2016;11(2):226-7.
22. Allen M, Ghosh S, Ahern GP, Villapol S, Maguire-Zeiss KA, Conant K. Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1. Sci Rep. 2016;6:35497.
2015
21. Villapol S, Saavedra JM. Neuroprotective effects of angiotensin receptor blockers. Am J Hypertens. 2015;28(3):289-99.
20. Villapol S, Kryndushkin D, Balarezo MG, Campbell AM, Saavedra JM, Shewmaker FP, et al. Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan. Am J Pathol. 2015;185(10):2641-52.
19. Villapol S, Balarezo MG, Affram K, Saavedra JM, Symes AJ. Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Brain. 2015;138(Pt 11):3299-315.
2014
18. Villapol S, Byrnes KR, Symes AJ. Temporal dynamics of cerebral blood flow, cortical damage, apoptosis, astrocyte-vasculature interaction and astrogliosis in the pericontusional region after traumatic brain injury. Front Neurol. 2014;5:82.
17. Susarla BT, Villapol S, Yi JH, Geller HM, Symes AJ. Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice. ASN Neuro. 2014;6(3):159-70.
2013
16. Villapol S, Wang Y, Adams M, Symes AJ. Smad3 deficiency increases cortical and hippocampal neuronal loss following traumatic brain injury. Exp Neurol. 2013;250:353-65.
15. Logan TT, Villapol S, Symes AJ. TGF-beta superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury. PLoS One. 2013;8(3):e59250.
14. Hafko R, Villapol S, Nostramo R, Symes A, Sabban EL, Inagami T, et al. Commercially available angiotensin II At(2) receptor antibodies are nonspecific. PLoS One. 2013;8(7):e69234.
2012
13. Villapol S, Yaszemski AK, Logan TT, Sanchez-Lemus E, Saavedra JM, Symes AJ. Candesartan, an angiotensin II AT(1)-receptor blocker and PPAR-gamma agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 2012;37(13):2817-29.
12. Charriaut-Marlangue C, Bonnin P, Gharib A, Leger PL, Villapol S, Pocard M, et al. Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. Stroke. 2012;43(11):3078-84.
11. Bonnin P, Leger PL, Villapol S, Deroide N, Gressens P, Pocard M, et al. Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia. Exp Neurol. 2012;236(1):50-7.
2011
10. Villapol S, Fau S, Renolleau S, Biran V, Charriaut-Marlangue C, Baud O. Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. Pediatr Res. 2011;69(1):51-5.
2009
9. Villapol S, Bonnin P, Fau S, Baud O, Renolleau S, Charriaut-Marlangue C. Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain. Am J Pathol. 2009;175(5):2111-20.
8. Gelot A, Villapol S, Billette de Villemeur T, Renolleau S, Charriaut-Marlangue C. Astrocytic demise in the developing rat and human brain after hypoxic-ischemic damage. Dev Neurosci. 2009;31(5):459-70.
2008
7. Villapol S, Gelot A, Renolleau S, Charriaut-Marlangue C. Astrocyte responses after neonatal ischemia: the yin and the yang. Neuroscientist. 2008;14(4):339-44.
6. Villapol S, Acarin L, Faiz M, Castellano B, Gonzalez B. Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain. Neuroscience. 2008;153(1):108-19.
5. Faiz M, Acarin L, Villapol S, Schulz S, Castellano B, Gonzalez B. Substantial migration of SVZ cells to the cortex results in the generation of new neurons in the excitotoxically damaged immature rat brain. Mol Cell Neurosci. 2008;38(2):170-82.
2007
4. Villapol S, Acarin L, Faiz M, Castellano B, Gonzalez B. Distinct spatial and temporal activation of caspase pathways in neurons and glial cells after excitotoxic damage to the immature rat brain. J Neurosci Res. 2007;85(16):3545-56.
3. Spiegler M, Villapol S, Biran V, Goyenvalle C, Mariani J, Renolleau S, et al. Bilateral changes after neonatal ischemia in the P7 rat brain. J Neuropathol Exp Neurol. 2007;66(6):481-90.
2. Acarin L, Villapol S, Faiz M, Rohn TT, Castellano B, Gonzalez B. Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation. Glia. 2007;55(9):954-65.
2006
1. Faiz M, Acarin L, Peluffo H, Villapol S, Castellano B, Gonzalez B. Antioxidant Cu/Zn SOD: expression in postnatal brain progenitor cells. Neurosci Lett. 2006;401(1-2):71-6.
Book Chapters
1. Book: Trends in Cell Signaling Pathways in Neuronal fate decision. Role of TGF-β Signaling in Neurogenic Regions After Brain Injury. Sonia Villapol, Trevor T. Logan, Aviva J. Symes. ISBN 978-953-51-1059-0, Hard cover, 358 pages, Publisher: InTech, Published: March 27, 2013
2. Book: Amyloidosis. Neuropathology of traumatic brain injury and its role in the development of Alzheimer’s Disease. Sonia Villapol. IntechOpen, 2018. DOI: 10.5772/intechopen.81945.
3. Book: Concussion and Traumatic Encephalopathy. Polypathology and Dementia After Brain Trauma: Does Brain Injury Trigger Distinct Neurodegenerative Diseases, or Should They be Classified Together as Traumatic Encephalopathy Washington PM, Villapol S, Burns MP. Edited by Dr. Jeff Victoroff and Dr. Erin D. Bigler. Chapter 13, Pages 573-582, 2018. Cambridge University Press. ISBN: 9781139696432.
4. Book: Fisiopatología de la COVID-19 en diferentes órganos y sistemas. Sonia Villapol. 6.- ALTERACIONES GASTROINTESTINALES. 6.1.- Fisiopatología de las alteraciones gastrointestinales durante la infección por SARS-Cov2. 6.2.- Fisiopatología de las alteraciones hepáticas durante la infección por SARS-Cov2. Elsevier, fall 2021.
5. Book: Neuroprotection: Methods and Protocols of the series METHODS IN MOLECULAR BIOLOGY. “iDISCO tissue clearing whole-brain and light sheet microscopy for high-throughput imaging in a mouse model of traumatic brain injury”. Hannah Flinn, Leonardo Cruz-Pineda, Laura Montier, Philip J. Horner and Sonia Villapol. Springer Nature. 2023, in press.
6. Book: Understanding the Behavioral and Medical Impact of Long COVID: An Empirical Guide to Assessment and Treatment of Post-Acute Sequelae of SARS CoV-2 Infection. “Chapter 6. Gastrointestinal Disorders”. Sonia Villapol. Jason, L.A., & Lapp, C. (Eds.)(2022). New York, NY: Routledge.
7. Book: The role of the microbiota–gut–brain axis on the neurobiology of infectious diseases. GZ Réus, S Villapol, T Barichello – Neurobiology of Infectious Diseases, 2025